- von Willebrand disease
inherited blood disorder (blood disease) characterized by a prolonged bleeding time and a deficiency of factor VIII, an important blood-clotting agent. This disorder is due to deficiencies in von Willebrand factor (vWF), a molecule that facilitates platelet adhesion and is a plasma carrier for factor VIII. Symptoms usually include abnormal bruising, bleeding from mucosal surfaces such as the gums and the gastrointestinal tract, and prolonged bleeding from any break in the skin or during surgery. The level of vWF and the severity of the disease vary over time, often as a result of hormonal or immune responses.Von Willebrand disease types 1 and 2 are milder forms and are inherited as autosomal dominant traits; type 3, the most severe form, is recessive and requires that the trait be inherited from both parents. The disease is treated with desmopressin (DDAVP), a drug that increases levels of factor VIII and vWF, or plasma-derived factor VIII preparations. See also thrombocytopathy.
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von Willebrand disease — von Willebrand disease. См. болезнь фон Виллебранда. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) … Молекулярная биология и генетика. Толковый словарь.
Von Willebrand disease — Infobox Disease Name = Von Willebrand disease Caption = DiseasesDB = 14007 ICD10 = ICD10|D|68|0|d|65 ICD9 = ICD9|286.4 ICDO = OMIM = 193400 MedlinePlus = eMedicineSubj = ped eMedicineTopic = 2419 MeshID = D014842Von Willebrand disease (vWD) is… … Wikipedia
von Willebrand disease — a congenital bleeding disorder, usually of autosomal dominant inheritance, characterized by deficiency of von Willebrand factor, with prolonged bleeding time and often impairment of adhesion of platelets on glass beads, associated with epistaxis… … Medical dictionary
von Willebrand disease — noun An hereditary disease, characterized by a tendency to hemorrhage, and caused by a defect in blood platelet activity … Wiktionary
von Willebrand disease factor — von Wil·le·brand disease, factor (fōn vilґə brahnt) [Erik Adolf von Willebrand, Finnish physician, 1870â€“1949] see under disease and factor … Medical dictionary
Von Willebrand factor — (vWF) is a blood glycoprotein involved in hemostasis. It is deficient or defective in von Willebrand disease and is involved in a large number of other diseases, including thrombotic thrombocytopenic purpura, Heyde s syndrome, and possibly… … Wikipedia
von Willebrand factor — von Wil·le·brand factor vän vil ə .bränt n a protein secreted esp. by endothelial cells that circulates in blood plasma as a large variable aggregation consisting usu. of repeating dimers, that mediates platelet adhesion to collagen in… … Medical dictionary
von Willebrand — E.A., Finnish physician, 1870–1949. See von Willebrand disease … Medical dictionary
von Willebrand's disease — von Wil·le·brand s disease .bränts n a genetic disorder that is caused by deficient or defective von Willebrand factor, is characterized by mucosal and petechial bleeding due to abnormal blood vessels, and is inherited chiefly as an autosomal… … Medical dictionary
von Willebrand's disease — an inherited disorder of the blood that is characterized by episodes of spontaneous bleeding similar to haemophilia. It is due to a variety of abnormalities of the von Willebrand factor, a glycoprotein necessary for normal platelet function. This … Medical dictionary