Tonegawa Susumu

Tonegawa Susumu

▪ Japanese biologist
born Sept. 5, 1939, Nagoya, Japan

      Japanese molecular biologist who was awarded the Nobel Prize for Physiology or Medicine in 1987 for his discovery of the genetic mechanisms underlying the great diversity of antibodies (antibody) produced by the vertebrate immune system.

      Tonegawa earned a B.S. degree from Kyōto University in 1963 and a Ph.D. in molecular biology from the University of California at San Diego, U.S., in 1969. He was a member of the Basel Institute for Immunology in Switzerland from 1971 to 1981. During that time Tonegawa applied the newly devised recombinant DNA techniques of molecular biology to immunology and began to tackle one of the greatest unsolved immunological questions of the day: how antibody diversity is generated. Prior to Tonegawa's discovery, it was unclear how a limited number of genes—there are believed to be about 100,000 in the human genome—could produce the total human antibody repertoire, which numbers in the trillions. According to Tonegawa's research, each antibody protein is not encoded by a specific gene, as one theory contended; instead, antibodies are constructed from a relatively small number of gene fragments (B cell) that are rearranged randomly to generate different antibody molecules.

      In 1981 Tonegawa moved to the United States to become a professor of biology at the Center for Cancer Research at the Massachusetts Institute of Technology (MIT). In addition to conducting immunological investigations, Tonegawa studied molecular and cellular aspects of neurobiology, and in 1994 he joined MIT's Center for Learning and Memory (now the Picower Institute for Learning and Memory). His research focused on the role of the hippocampus in the processes of memory formation and recall. To conduct these studies, Tonegawa developed a genetically engineered mouse model in which the animals were no longer able to produce an enzyme called calcineurin. Calcineurin plays important roles in the immune system and in the brain, where it is associated with receptors that bind chemicals involved in neural synaptic transmission. Tonegawa's mice unexpectedly displayed symptoms characteristic of schizophrenia. Further studies indicated that genetic variations in the calcineurin gene contribute to the development of schizophrenia in humans. Tonegawa's mouse model has since been employed for the discovery of pharmacological agents for the treatment of schizophrenia. Tonegawa also identified genes and proteins involved in long-term memory storage, and he developed techniques to facilitate the study of neuronal circuits involved in cognition and behaviour.

      Tonegawa received numerous awards throughout his career, including the Louisa Gross Horwitz Prize (1982), the Person of Cultural Merit prize (Bunka Korosha; 1983), conferred by the Japanese government, and the Order of Culture (Bunka Kunsho; 1984).

* * *


Universalium. 2010.

Игры ⚽ Нужна курсовая?

Look at other dictionaries:

  • Tonegawa Susumu — (jap. 利根川 進 Tonegawa Susumu, * 6. September 1939 in Nagoya) ist ein japanischer Molekularbiologe und Immunologe. Er erhielt 1981 den Asahi Preis und den Avery Landsteiner Preis, 1983 einen Gairdner Foundation International Award, 1986 den Robert… …   Deutsch Wikipedia

  • Tonegawa , Susumu — (1939–) Japanese immunologist Tonegawa was born at Nagoya in Japan and educated at Kyoto University and the University of California, San Diego. He worked at the Basle Institute for Immunology from 1971 and in 1981 was appointed professor of… …   Scientists

  • Tonegawa, Susumu — ► (n. 1939) Científico japonés. Fue premio Nobel de Medicina y Fisiología en 1987 por sus investigaciones sobre el sistema inmunitario del ser humano y por sus estudios sobre la fabricación de anticuerpos por el organismo …   Enciclopedia Universal

  • Tonegawa Susumu — noun Japanese molecular biologist noted for his studies of how the immune system produces antibodies (born in 1939) • Instance Hypernyms: ↑molecular biologist …   Useful english dictionary

  • Tonegawa — Tonegawa, Susumu …   Enciclopedia Universal

  • Susumu Tonegawa — Tonegawa Susumu (jap. 利根川 進 Tonegawa Susumu, * 6. September 1939 in Nagoya) ist ein japanischer Molekularbiologe und Immunologe. Er erhielt 1986 den Robert Koch Preis und 1987 den Nobelpreis für Medizin für die Entdeckung der genetischen… …   Deutsch Wikipedia

  • Susumu Tonegawa — (利根川 進 Tonegawa Susumu, né à Nagoya au Japon, le 6 septembre 1939) est un savant japonais qui a obtenu le Prix Nobel de physiologie ou médecine en 1987 pour « sa découverte du principe génétique de la génération de la diversité des anticorps …   Wikipédia en Français

  • TONEGAWA S. — TONEGAWA S. TONEGAWA SUSUMU (1939 ) Immunogénéticien, Tonegawa est l’exemple le plus accompli de ce nouveau type de chercheurs que le second conflit mondial a fait éclore. Né à Nagoya, au Japon, il a travaillé dans son pays d’origine, à Kyot 拏,… …   Encyclopédie Universelle

  • Tonegawa — Tonegawa,   Susumu, japanischer Molekularbiologe, * Nagoya 5. 9. 1939; seit 1981 Professor am Krebsforschungsinstitut des MIT; erhielt 1987 den Nobelpreis für Physiologie oder Medizin für die Erforschung der genetischen Grundlagen der… …   Universal-Lexikon

  • Susumu Tonegawa — Infobox Scientist name =Susumu Tonegawa box width = image width =150px caption = Susumu Tonegawa birth date = birth date and age|1939|09|06 birth place = Nagoya, Japan death date = death place = residence = citizenship = nationality = Japan… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”