agranulocytosis

agranulocytosis
/euh gran'yeuh loh suy toh"sis/, n. Pathol.
a serious, acute blood disease, sometimes related to drug or radiation therapy, characterized by extreme leukopenia, fever, and ulcerations of the mucous membranes.
[1925-30; A-6 + GRANULOCYTE + -OSIS]

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also called  agranulocytic angina  

      acute infection characterized by severe sore throat, fever, and fatigue and associated with an extreme reduction of white blood cells, or leukocytes (leukocyte) (a condition known as leukopenia), particularly the white cells known as neutrophils (neutropenia).

      In most cases, agranulocytosis appears to develop as a result of sensitization to certain drugs and chemicals; infection then follows as a consequence, not a cause, of the profound neutropenia. First observed as a reaction to the coal-tar product aminopyrine, agranulocytosis is triggered by a variety of pain relievers (analgesics), tranquilizers, antihistamines, anticonvulsants, sulfonamide derivatives, and antithyroid drugs. It also is a frequent complication of cancer treatment. Treatment of agranulocytosis consists of the immediate and permanent withdrawal of the offending drug and control of the infection with antibiotics.

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Universalium. 2010.

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Look at other dictionaries:

  • Agranulocytosis — is an acute condition involving a severe and dangerous leukopenia particularly of neutrophils causing a neutropenia in the circulating blood. [ [http://www.emedicine.com/asp/dictionary.asp?keyword=agranulocytosis eMedicine/Stedman Medical… …   Wikipedia

  • agranulocytosis — agranulocytosis. См. болезнь Костманна. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • agranulocytosis — [ā gran΄yo͞o lō΄sī tō′sis] n. [ A 2 + GRANULOCYT(E) + OSIS] a disorder characterized by a significant decrease of granulocytes in the blood and often resulting in high fever, weakness, and ulceration of the mucous membranes …   English World dictionary

  • Agranulocytosis — A marked decrease in the number of granulocytes. Granulocytes are a type of white blood cell filled with microscopic granules that are little sacs containing enzymes that digest microorganisms. Granulocytes are part of the innate, somewhat non… …   Medical dictionary

  • Agranulocytosis, infantile genetic — Children born with this condition lack neutrophils (a type of white blood cell that is important in fighting infection). These children suffer frequent infections from bacteria which in the past led to death in three quarters of cases before 3… …   Medical dictionary

  • agranulocytosis — noun (plural agranulocytoses) Etymology: New Latin Date: 1927 an acute febrile condition marked by severe decrease in blood granulocytes and often associated with the use of certain drugs …   New Collegiate Dictionary

  • agranulocytosis — Severe acute deficiency of granulocytes in blood …   Dictionary of molecular biology

  • agranulocytosis — noun An acute condition involving a severe and dangerous leukopenia, particularly of neutrophils, causing a neutropenia in the circulating blood …   Wiktionary

  • agranulocytosis — n. disease characterized by a high fever and a reduced number of white blood cells (Medicine) …   English contemporary dictionary

  • agranulocytosis — [əˌgranjʊlə(ʊ)sʌɪ təʊsɪs] noun Medicine a deficiency of granulocytes in the blood, causing increased vulnerability to infection …   English new terms dictionary

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