Prontosil


Prontosil

drug
also called  sulfamidochrysoidine 

      trade name of the first synthetic drug used in the treatment of general bacterial infections in humans. Prontosil was introduced into medicine in the 1930s.

      Prontosil resulted from research, directed by German chemist and pathologist Gerhard Domagk (Domagk, Gerhard), on the antibacterial action of azo dyes (azo dye). A red azo dye of low toxicity, Prontosil was shown by Domagk to prevent mortality in mice infected with Streptococcus bacteria. The dye was also effective in controlling Staphylococcus infections in rabbits. Within a relatively short period, it was demonstrated that Prontosil was effective not only in combating experimental infections in animals but also against streptococcal diseases in humans, including meningitis and puerperal sepsis. Later it was found that Prontosil is disrupted in the tissues to form para-aminobenzenesulfonamide (sulfanilamide).

      Prontosil has been replaced in clinical use by newer sulfonamide drugs, including sulfanilamide, sulfathiazole, sulfamethoxazole, and others.

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Universalium. 2010.

Look at other dictionaries:

  • Prontosil — chlorhydrate de prontosil Général Nom IUPAC 4 (2,4 diaminophényl) diazénylbenzènesulfonamide …   Wikipédia en Français

  • Prontosil — Saltar a navegación, búsqueda Imagen en 3D de la molécula del Prontosil (Sulfamidocrisoidina) El Prontosil fue el primer fármaco de síntesis con acción bactericida amplia. Su número CAS de registro es 103 12 8. Su nombre químico es p ((2,4… …   Wikipedia Español

  • Prontosil — drugbox IUPAC name = 4 [(2,4 diaminophenyl)azo] benzenesulfonamide CAS number = 103 12 8 ATC prefix = ATC suffix = ATC supplemental = PubChem = 66895 DrugBank = C=12 | H=13 | N=5 | O=2 | S=1 molecular weight = 291.33 g/mol bioavailability =… …   Wikipedia

  • Prontosil — The first sulfa drug to be discovered. Largely of historic interest today. The discovery was made by the great German physician and chemist Gerhard Domagk (1895 1964). In 1925 Domagk was named Lecturer in Pathologic Anatomy (pathology) in the… …   Medical dictionary

  • Prontosil — Strukturformel Allgemeines Name Sulfamidochrysoidin Andere Namen 4 (2,4 Diaminophenyl) diazenylbenzensulfonamid …   Deutsch Wikipedia

  • prontosil — ˈpräntəˌsil noun ( s) Etymology: German : any of three sulfonamide drugs: a. or prontosil rubrum : a red azo dye H2NSO2C6H4N . NC6H3(NH2) …   Useful english dictionary

  • Prontosil — Pron|to|sil das; s Kunstw.> in seiner Heilwirkung zuerst 1932 entdecktes ↑Sulfonamid …   Das große Fremdwörterbuch

  • prontosil — pron·to·sil …   English syllables

  • prontosil rubrum — prontosil ru·brum rü brəm n PRONTOSIL (a) …   Medical dictionary

  • prontosil album — prontosil al·bum al bəm n SULFANILAMIDE …   Medical dictionary


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