polymyositis


polymyositis

      chronic, progressive inflammation of skeletal muscles (muscle), particularly the muscles of the shoulders and pelvis.

      Initially muscles may be swollen slightly, and the first symptoms to appear are usually muscle weakness and sometimes pain. A weakening of muscles close to the torso is common. Occasionally muscles of the esophagus and larynx are affected, which causes difficulty in swallowing and speaking. When muscles of the lungs (lung) are involved, difficulty in breathing may result. Muscles of the heart and the gastrointestinal tract also may be affected. As the disease progresses, the affected muscles atrophy and harden. Symptoms may occur in alternating cycles of remission and exacerbation.

      The muscle cell damage that occurs in polymyositis is thought to result from an attack on muscle tissue by white blood cells called T lymphocytes (lymphocyte), which normally are produced by the immune system to fight infection. The factor that precipitates this autoimmune response is not known, but there is evidence that viral infections trigger some cases of polymyositis.

      Polymyositis is more prevalent in women. It sometimes is associated with an increased incidence of several types of malignancies, including lung (lung cancer), colon (colorectal cancer), and breast cancers (breast cancer). The disorder dermatomyositis, which involves the skin as well as the muscles, shares many characteristics with polymyositis, but the two are believed to arise from different causes.

      The medications most commonly used to treat polymyositis are corticosteroids, such as prednisone, which reduce inflammation. A number of immunosuppressive medications, such as methotrexate, also are used. Early diagnosis and treatment tends to reduce the severity of the disease.

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Universalium. 2010.

Look at other dictionaries:

  • Polymyosītis — Polymyosītis, soviel wie Dermatomyositis …   Meyers Großes Konversations-Lexikon

  • Polymyositis — Polymyositis,   entzündliche Erkrankung mehrerer Muskeln oder Muskelgruppen; im engeren Sinn eine zu den Autoimmunkrankheiten gerechnete, oft mit Hautveränderungen (Dermatomyositis) und verschiedenen Kollagenkrankheiten verbundene, entzündlich… …   Universal-Lexikon

  • Polymyositis — Infobox Disease Name = PAGENAME Caption = DiseasesDB = 10343 ICD10 = ICD10|M|33|2|m|30 ICD9 = ICD9|710.4 ICDO = OMIM = MedlinePlus = 000428 eMedicineSubj = med eMedicineTopic = 3441 eMedicine mult = eMedicine2|emerg|474 MeshID =… …   Wikipedia

  • Polymyositis — Klassifikation nach ICD 10 M33.2 Polymyositis …   Deutsch Wikipedia

  • Polymyositis — A chronic inflammatory disease of muscle that begins when white blood cells, the immune cells of inflammation, spontaneously invade muscles, especially the muscles closest to the trunk or torso, resulting in sometimes severe muscle pain,… …   Medical dictionary

  • polymyositis — noun myositis characterized by weakness of limb and neck muscles and much muscle pain and swelling; progression and severity vary among individuals (Freq. 1) • Hypernyms: ↑myositis * * * |pälē, lə̇+ noun Etymology: New Latin, from poly + myositis …   Useful english dictionary

  • polymyositis — An inflammatory disease of the muscles closest to the center of the body. It causes weakness, inability to stand, climb stairs, lift, or reach. It may also cause muscle pain and difficulty swallowing, and may affect the lungs and heart. Having… …   English dictionary of cancer terms

  • polymyositis — noun Date: 1878 inflammation of several muscles at once; specifically an inflammatory muscle disease of unknown cause that affects skeletal muscles chiefly closest to the trunk and is characterized especially by muscle weakness and muscle and… …   New Collegiate Dictionary

  • polymyositis — noun An inflammatory disease affecting multiple muscles …   Wiktionary

  • polymyositis — n. progressive disease of the skeletal muscle characterized by weakness scleroderma and rheumatism (Medicine) …   English contemporary dictionary


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