Fibiger, Johannes

Fibiger, Johannes

▪ Danish pathologist
in full  Johannes Andreas Grib Fibiger  
born April 23, 1867, Silkeborg, Den.
died Jan. 30, 1928, Copenhagen
 Danish pathologist who received the Nobel Prize for Physiology or Medicine in 1926 for achieving the first controlled induction of cancer in laboratory animals, a development of profound importance to cancer research.

      A student of the bacteriologists Robert Koch and Emil von Behring in Berlin, Fibiger became professor of pathological anatomy at the University of Copenhagen (1900). In 1907, while dissecting rats infected with tuberculosis, he found tumours in the stomachs of three animals. After intensive research, he concluded that the tumours, apparently malignant, followed an inflammation of stomach tissue caused by the larvae of a worm now known as Gongylonema neoplasticum. The worms had infected cockroaches eaten by the rats.

      By 1913 he was able to induce gastric tumours consistently in mice and rats by feeding them cockroaches infected with the worm. By showing that the tumours underwent metastasis, he added important support to the then-prevailing concept that cancer is caused by tissue irritation. Fibiger's work immediately led the Japanese pathologist Yamagiwa Katsusaburo to produce cancer in laboratory animals by painting their skins with coal-tar derivatives, a procedure soon adopted by Fibiger himself. While later research revealed that the Gongylonema larvae were not directly responsible for the inflammation, Fibiger's findings were a necessary prelude to the production of chemical carcinogens (cancer-causing agents), a vital step in the development of modern cancer research.

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Universalium. 2010.

Look at other dictionaries:

  • Fibiger, Johannes — ► (1867 1928) Médico danés. Fue premio Nobel de Medicina y Fisiología en 1926, por sus estudios sobre el cáncer …   Enciclopedia Universal

  • Fibiger , Johannes Andreas Grib — (1867–1928) Danish physician Fibiger, born the son of a physician at Silkeborg in Denmark, was educated at the University of Copenhagen, completing his medical studies in 1890. After some hospital work and further study in Berlin under Robert… …   Scientists

  • Fibiger, Johannes Andreas Grib — born April 23, 1867, Silkeborg, Den. died Jan. 30, 1928, Copenhagen Danish pathologist. He found that rats that had suffered stomach tissue inflammation caused by the larvae of a worm infecting cockroaches the rats had eaten subsequently… …   Universalium

  • Fibiger, Johannes Andreas Grib — (23 abr. 1867, Silkeborg, Dinamarca–30 ene. 1928, Copenhague). Patólogo danés. Descubrió que las ratas que habían sufrido una gastritis, causada por las larvas de un gusano que infectaba ciertas cucarachas, que les servían de alimento,… …   Enciclopedia Universal

  • Fibiger — Fibiger, Johannes …   Enciclopedia Universal

  • Johannes Fibiger — Johannes Andreas Grib Fibiger Pour les articles homonymes, voir Fibiger. Johannes Andreas Grib Fibiger Johannes Andreas Grib Fibiger est un médecin …   Wikipédia en Français

  • Fibiger — Fibiger,   Johannes, dänischer Pathologe, * Silkeborg 23. 4. 1867, ✝ Kopenhagen 30. 1. 1928; ab 1900 Professor in Kopenhagen; war Mitarbeiter Robert Kochs und E. von Behrings. Nach experimentellen Studien zur Krebserzeugung bei Ratten und Mäusen… …   Universal-Lexikon

  • Johannes Andreas Grib Fibiger — Pour les articles homonymes, voir Fibiger. Johannes Andreas Grib Fibiger Johannes Andreas Grib Fibiger (23 avril 1867 à Silkeborg, Danemark …   Wikipédia en Français

  • johannes — /joh han eez, is/, n., pl. johannes. a gold coin formerly used as currency in Portugal, first issued in the early 18th century. Also, joannes. [1750 60, Amer.; after the name Joannes (John V, of Portugal) in the coin s legend. See JOHN] * * * (as …   Universalium

  • Johannes — /yoh hah nis, han is/, n. a male given name, form of John. * * * (as used in expressions) Berg Alban Maria Johannes Brahms Johannes Brinkman Johannes Andreas Johannes Scotus Eriugena Ewald Johannes Fibiger Johannes Andreas Grib Johannes Frobenius …   Universalium

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