A method of determining the curve that best describes the relationship between expected and observed sets of data by minimizing the sums of the squares of deviation between observed and expected values.
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Least squares inference in phylogeny — generates a phylogenetic tree based on anobserved matrix of pairwise genetic distances andoptionally a weightmatrix. The goal is to find a tree which satisfies the distance constraints asbest as possible.Ordinary and weighted least squaresThe… … Wikipedia