- Vane, Sir John Robert
▪ 2005British pharmacologist (b. March 29, 1927, Tardebigg, Worcestershire, Eng.—d. Nov. 19, 2004, Farnborough, Kent, Eng.), conducted pioneering research in the study of hormonelike substances in the body called prostaglandins; he shared the 1982 Nobel Prize for Physiology or Medicine with Swedish biochemists Sune K. Bergström (q.v. (Bergstrom, Sune Karl )) and Bengt I. Samuelsson. Vane discovered in 1971 that the beneficial effects of aspirin, which include the reduction of fever, pain, inflammation, and blood-clot formation, were the result of aspirin's property of blocking the formation of prostaglandins and related substances. His research led to the discovery of prostacyclin, a prostaglandin derivative that is important for the health of blood vessels, and to the development of ACE (angiotensin-converting enzyme) inhibitors, widely used in the treatment of high blood pressure. Vane received a doctorate (1953) in pharmacology at St. Catherine's College, Oxford. He joined (1955) the faculty of the Institute of Basic Medical Sciences, London, and later became the director (1973) of research and development at the Wellcome Foundation. He was also the founding director (1986) of the William Harvey Research Institute, London, which specialized in cardiovascular research. Vane was knighted in 1984.
* * *▪ British biochemistborn March 29, 1927, Tardebigg, Worcestershire, Englanddied November 19, 2004, Farnborough, HampshireEnglish biochemist who, with Sune K. Bergström (Bergström, Sune K.) and Bengt Ingemar Samuelsson (Samuelsson, Bengt Ingemar), won the Nobel Prize for Physiology or Medicine in 1982 for the isolation, identification, and analysis of prostaglandins, which are biochemical compounds that influence blood pressure, body temperature, allergic reactions, and other physiological phenomena in mammals.Vane graduated from the University of Birmingham in 1946 and earned a doctorate at the University of Oxford in 1953. He spent several years on the faculty of Yale University (1953–55) in the United States before returning to England to join the Institute of Basic Medical Sciences of the University of London. In 1973 he became research director of the Wellcome Research Laboratories in Beckenham, Kent, a post he held until 1985. In 1986 Vane founded the William Harvey Research Institute, attached to St. Bartholomew's Hospital in London, which funded cardiovascular research. He remained with the institute, in various positions, until his death.As part of his Nobel Prize-winning work, Vane demonstrated that aspirin inhibits the formation of prostaglandins associated with pain, fever, and inflammation, thus providing a physiological rationale for the effectiveness of the world's most widely used drug. He also discovered prostacyclin, an important prostaglandin that plays a vital role in the process of blood coagulation.Vane, the recipient of numerous honours, was elected a fellow of the Royal Society in 1974 and was made an honorary member of the American Academy of Arts and Sciences in 1982. He was knighted in 1984.
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Vane , Sir John Robert — (1927–) British pharmacologist Vane studied chemistry at the University of Birmingham and pharmacology at Oxford, where he obtained his DPhil in 1953. He then worked at the Royal College of Surgeons, serving as professor of experimental… … Scientists
John Robert Vane — John Vane John Vane (né le 29 mars 1927, mort le 19 novembre 2004), était un médecin et pharmacologue britannique, lauréat du prix Nobel de médecine. Biographie Sir John Robert Vane est né le 29 mars 1927 à Tardebigg dans le… … Wikipédia en Français
John Robert Vane — Infobox Scientist name = John Robert Vane box width = image width =150px caption =John Robert Vane birth date = March 29, 1927 birth place = death date = November 19, 2004 death place = residence = citizenship = nationality = British ethnicity =… … Wikipedia
Medizinnobelpreis 1982: Sune Bergström — Bengt Ingemar Samuelsson — John Robert Vane — Die beiden Schweden und der Brite wurden für ihre Entdeckung der Prostaglandine und verwandte biologisch aktive Substanzen ausgezeichnet. Biografien Sune Karl Bergström, * Stockholm 10. 1. 1916; 1947 58 Professor in Lund und dann bis 1980… … Universal-Lexikon
Vane — Sir John Robert … Scientists
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John Vane — Sir John Vane (né le 29 mars 1927 et mort le 19 novembre 2004), était un médecin et pharmacologue britannique, lauréat du prix Nobel de médecine. Biographie John Robert Vane est né à Tardebigg dans le Worcestershire. Son père… … Wikipédia en Français