uterine cancer


uterine cancer
Malignant tumour of the uterus.

Cancers affecting the lining of the uterus (endometrium) are the most common cancers of the female reproductive tract. Risk factors include absence of pregnancy, early age of first menstruation (before age 12), late onset of menopause (after age 52), obesity, diabetes, and estrogen replacement therapy. Additional risk factors are a personal history of breast or ovarian cancer, age (over age 40), and a family history of uterine cancer. Whites are more likely to develop uterine cancer than are blacks. The major symptom is vaginal bleeding or discharge. Treatment may begin with simple or radical hysterectomy. Some uterine cancers are treated in part by hormonal therapy, radiation therapy, or chemotherapy.

* * *

Introduction

      a disease characterized by the abnormal growth of cells in the uterus. Cancers affecting the lining of the uterus (endometrium) are the most common cancers of the female reproductive tract. Other uterine cancers, called uterine sarcomas, develop from underlying muscle or connective tissue; they are much rarer. This article focuses on the development, diagnosis, and treatment of endometrial cancer.

Causes and symptoms
      Although the causes of endometrial cancer vary and in many cases remain unknown, several factors have been identified that increase the risk of developing the disease. Many of these risk factors stem from an imbalance in which levels of the hormone estrogen in the uterus are regularly higher than levels of progesterone. Women who began their menstrual cycles at an early age (before 12 years) or who entered menopause late (after age 52) are at a higher risk for endometrial cancer, probably because of the increased exposure of the uterine wall to estrogen. Other factors associated with increased exposure to estrogen include lack of a previous pregnancy, obesity, and estrogen replacement therapy following menopause. Women who have taken the breast cancer drug tamoxifen also appear to be at slightly higher risk of developing endometrial cancer, as are females with diabetes. Additional risk factors include race—whites are 70 percent more likely to develop uterine cancer than are blacks—a personal history of breast or ovarian cancer, age (over 40 years), and a family history of endometrial cancer.

      The predominant early sign of endometrial cancer is vaginal bleeding or other discharge, especially in postmenopausal women. Any such discharge should be brought to the attention of a physician immediately. Additional possible symptoms are unexplained pelvic pain, a discernible lump or mass, and weight loss.

Diagnosis and prognosis
      A biopsy may be used to take samples of uterine tissue, or dilatation and curettage (D & C) may be used to scrape endometrial cells from the wall of the uterus for examination. Cancers of the uterus and surrounding tissues can also be detected by observing the reproductive, digestive, and urinary tracts with specialized viewing scopes. Internal imaging (diagnostic imaging) procedures often allow a more precise location and determination of the potential spread of uterine cancer. Methods include X rays, computed tomography (computerized axial tomography) (CT) scans, magnetic resonance imaging (diagnosis) (MRI), and ultrasound (diagnosis). An X-ray procedure called an intravenous pyelogram uses an injected iodine solution to enhance a series of images taken of the urinary tract in cases where spread of cancer to these tissues is suspected.

      Once uterine cancer has been diagnosed, its stage is then determined to indicate how far the cancer has progressed. Stage I cancers are localized to the main body of the uterus, whereas stage II tumours have spread to the cervix. Stage III cancers have spread outside the uterus to the vagina, regional lymph nodes, or peritoneum but are still contained within the pelvis. Stage IV cancers have spread to distant organs such as the lungs, bone, bladder, or digestive tract.

      Five-year survival for endometrial cancer is quite high when the cancer is diagnosed early, even among patients whose cancer has spread to the cervix. If the cancer has spread beyond the endometrium but remains confined to the pelvis, five-year survival is roughly 50 percent. However, once the cancer has metastasized to other organs, the five-year survival rate is very low.

Treatment (therapeutics)
       surgery is used to treat most endometrial cancers. A simple hysterectomy removes the uterus and cervix, whereas a radical hysterectomy also removes underlying connective tissue (the parametrium) and ligaments along with the upper portion of the vagina. Either of these surgeries may be done in conjunction with the removal of the fallopian tubes and ovaries. Surgical removal of the uterus or ovaries results in infertility, and removal of the ovaries will also cause women to go immediately into menopause. Lymph nodes may also be removed during surgery. Radiation therapy is sometimes used in conjunction with surgery. External beam radiation resembles traditional X rays in that the radiation is directed from outside the body toward an internal target tissue. In brachytherapy radioactive rods or pellets are implanted to focus the radiation on the cancer and greatly reduce side effects. Side effects of pelvic radiation therapy may include diarrhea, fatigue, premature menopause, bladder irritation, or narrowing of the vagina due to scar tissue buildup.

      In cases where endometrial cancer has spread beyond the uterus, general or systemic approaches such as chemotherapy may be required so that as many cancerous cells as possible can be sought out and destroyed. Some uterine cancers can be treated in part by using hormonal therapy. If the cancer cells are found to contain a protein called the progesterone receptor, the hormone progesterone may be used to slow the growth of the tumour.

Prevention
      Long-term use of oral contraceptives (birth control pills) reduces the risk of endometrial cancer. Regular exams may reveal benign growths in the uterine wall called hyperplasias, which can be removed to eliminate the possibility of their developing into malignant tumours. Some medical societies recommend an annual Pap test (Pap smear) plus pelvic exam for all women once they have reached 18 years of age or become sexually active, whichever is earlier.

* * *


Universalium. 2010.

Look at other dictionaries:

  • uterine cancer — Cancer that forms in tissues of the uterus (small, hollow, pear shaped organ in a woman s pelvis in which a baby grows). Two types of uterine cancer are endometrial cancer (cancer that begins in cells lining the uterus) and uterine sarcoma (a… …   English dictionary of cancer terms

  • Uterine cancer — Classification and external resources Malignant tumor of the uterus ICD 10 C54 ICD …   Wikipedia

  • uterine sarcoma — A rare type of uterine cancer that forms in muscle or other tissues of the uterus (the small, hollow, pear shaped organ in a woman s pelvis in which a baby grows). It usually occurs after menopause. The two main types are leiomyosarcoma (cancer… …   English dictionary of cancer terms

  • Cancer, uterus — Cancer of the womb. Also referred to as uterine cancer. Cancer of the uterus occurs most often in women between the ages of 55 and 70 years. Abnormal bleeding after menopause is the most common symptom of cancer of the uterus. Cancer of the… …   Medical dictionary

  • Cancer — For other uses, see Cancer (disambiguation). Cancer Classification and external resources …   Wikipedia

  • uterine — adjective Etymology: Middle English, from Late Latin uterinus, from Latin uterus Date: 15th century 1. born of the same mother but by a different father < uterine brothers > 2. of, relating to, or affecting the uterus < uterine cancer > < the… …   New Collegiate Dictionary

  • uterine — Relating to the uterus. * * * uter·ine yüt ə .rīn, rən adj of, relating to, occurring in, or affecting the uterus <uterine tissue> <uterine cancer> * * * adj. of or relating to the uterus …   Medical dictionary

  • Uterine clear cell carcinoma — Classification and external resources ICD 10 C54.1 ICD 9 182 Uterine clear cell carcinom …   Wikipedia

  • Uterine fibroid — Uterine fibroids Classification and external resources Uterine Fibroids ICD 10 D25 …   Wikipedia

  • Cancer De L'endomètre — Le cancer de l endomètre, appelé aussi cancer du corps utérin, est le cancer qui se développe à partir de l endomètre qui est le tissu de l utérus où se produit la nidation. Il ne doit pas être confondu avec le cancer du col de l utérus car les… …   Wikipédia en Français


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.