Paget disease of bone


Paget disease of bone

Chronic bone disease of middle age.

Named for James Paget, it is characterized by excessive bone destruction alternating with disordered bone construction (with dense, brittle bones and deformity that can compress internal structures). The long bones, vertebrae, pelvis, and skull are most often affected, more often in men. The risk of cancer, usually osteosarcoma, is high. Increased blood supply to the area of bone destruction may lead to heart or circulatory problems. Calcitonin (which regulates bone growth) and bisphosphonates (which block excessive bone breakdown) are drugs of treatment.

* * *

also called  osteitis deformans  

      chronic disease of middle age, characterized by excessive breakdown and formation of bone tissue. The disease is common among people of northern European descent; it is almost nonexistent among people of Asian and African descent. The disease leads to deformities, fractures (fracture), and arthritis and may cause an increased risk of cancer, particularly osteosarcoma. The long bones, vertebrae, pelvis, and skull are most commonly affected, in men more often than in women. In the bone-destructive stages, bones soften and blood supply to the area increases, which may lead to heart or circulatory problems. In bone-constructive stages, bones are dense and brittle and fracture easily. Treatment includes the administration of medications such as biphosphonates or calcitonin, which inhibit bone cell activity. Individuals with Paget disease of bone should also exercise regularly and receive adequate daily amounts of calcium and vitamin D. The disease is named for the English surgeon and pathologist Sir James Paget (Paget, Sir James, 1st Baronet), who first described it.

* * *


Universalium. 2010.

Look at other dictionaries:

  • Paget disease of bone — A chronic condition in which both the breakdown and regrowth of bone are increased. Paget disease of bone occurs most frequently in the pelvic and leg bones, skull, and lower spine. It is most common in older individuals, and may lead to bone… …   English dictionary of cancer terms

  • Paget disease of bone — osteitis deformans …   Medical dictionary

  • Paget's disease of bone — For other diseases named after Paget, see Paget s disease (disambiguation). Paget s disease of bone Classification and external resources This 92 year old male patient presented for assessment of acute hemiparesis. An incidental finding was… …   Wikipedia

  • Paget's disease of bone — A chronic bone disorder that typically results in enlarged, deformed bones due to excessive breakdown and formation of bone tissue that can cause bones to weaken and may result in bone pain, arthritis, deformities or fractures. The disease is… …   Medical dictionary

  • bone cancer — ▪ disease Introduction       disease characterized by uncontrolled growth of cells of the bone. Primary bone cancer that is, cancer that arises directly in the bone is relatively rare. In the United States, for example, only about 2,400 new cases …   Universalium

  • bone disease — Introduction  any of the diseases or injuries that affect human bones (bone). Diseases and injuries of bones are major causes of abnormalities of the human skeletal system (skeletal system, human). Although physical injury, causing fracture,… …   Universalium

  • Paget-Syndrom — Klassifikation nach ICD 10 M88. Osteodystrophia deformans M88.0 Osteodystrophia deformans der Schädelknochen M88.8 …   Deutsch Wikipedia

  • bone — /bohn/, n., v., boned, boning, adv. n. 1. Anat., Zool. a. one of the structures composing the skeleton of a vertebrate. b. the hard connective tissue forming the substance of the skeleton of most vertebrates, composed of a collagen rich organic… …   Universalium

  • Bône — /bohn/, n. former name of Annaba. * * * I Rigid connective tissue of vertebrates, consisting of cells embedded in a hard matrix. Bones serve as the body s supporting framework, provide muscle attachment points for movement, protect the internal… …   Universalium

  • Paget, Sir James — born Jan. 11, 1814, Great Yarmouth, Norfolk, Eng. died Dec. 30, 1899, London British surgeon and physiologist. In 1834 he discovered the parasite that causes trichinosis. He gave excellent descriptions of breast cancer, Paget disease of breast… …   Universalium


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.