- Murad, Ferid
born Sept. 14, 1936, Whiting, Ind., U.S.U.S. pharmacologist.He received his M.D. and Ph.D. from Western Reserve University (later Case Western Reserve University). Murad showed that nitroglycerin and related heart drugs induce the formation of nitric oxide, a gas that increases the diameter of blood vessels. Along with Robert F. Furchgott and Louis J. Ignarro, he was awarded a 1998 Nobel Prize for the discovery that nitric oxide acts as a signaling molecule in the cardiovascular system. Their combined work uncovered an entirely new mechanism for how blood vessels relax and widen. This discovery led to the development of the drug Viagra, which is used to treat erectile dysfunction.
* * *▪ American scientistborn Sept. 14, 1936, Whiting, Ind., U.S.American pharmacologist, who, along with Robert F. Furchgott (Furchgott, Robert F.) and Louis J. Ignarro (Ignarro, Louis J.), was co-awarded the 1998 Nobel Prize in Physiology or Medicine for the discovery that nitric oxide (NO) acts as a signaling molecule in the cardiovascular system. Their combined work uncovered an entirely new mechanism for how blood vessels (blood vessel) in the body relax and widen.Murad received his M.D. and Ph.D. from Western Reserve University (later Case Western Reserve University) in Cleveland, Ohio, in 1965. In addition to his clinical practice, Murad taught pharmacology at the University of Virginia School of Medicine, Charlottesville (1975–81), at Stanford University (1981–89), and then at Northwestern University (1988). While at Stanford he ventured into the private sector as a vice president of Abbott Laboratories (1988–92) and then became president of the Molecular Geriatrics Corporation (1993–95). He began teaching at the medical school of the University of Texas, Houston, in 1997.In 1977 Murad showed that nitroglycerin and several related heart drugs induce the formation of nitric oxide and that the colourless, odourless gas acts to increase the diameter of blood vessels in the body. Furchgott and Ignarro built on this work. About 1980 Furchgott demonstrated that cells in the endothelium, or inner lining, of blood vessels produce an unknown signaling molecule, which he named endothelium-derived relaxing factor (EDRF). This molecule signals smooth muscle cells in blood vessel walls to relax, dilating the vessels. Ignarro's research, conducted in 1986 and done independently of Furchgott's work, identified EDRF as nitric oxide. These discoveries led to the development of the anti-impotence drug sildenafil citrate (Viagra) and had the potential to unlock new approaches for understanding and treating other diseases.The Nobel Assembly of the Karolinska Institute in Stockholm, which presented the prize, said that the identification of a biological role for nitric oxide was surprising for several reasons. Nitric oxide was known mainly as a harmful air pollutant, released into the atmosphere from automobile engines and other combustion sources. In addition, it was a simple molecule, very different from the complex neurotransmitters and other signaling molecules that regulate many biological events. No other gas is known to act as a signaling molecule in the body.Murad was also the recipient of the Albert Lasker Basic Medical Research Award in 1996 for his discovery. Murad and Ignarro collaborated on Nitric Oxide: Biochemistry, Molecular Biology, and Therapeutic Implications (1995).
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Murad Ferid — (* 11. April 1908 in Saloniki; † 11. Oktober 1998 in München) war ein deutscher Rechtswissenschaftler und ordentlicher Professor an der Universität München. Seine Schwerpunkte lagen im bürgerlichen Recht, im internationalen Privatrecht, im… … Deutsch Wikipedia
Murad , Ferid — (1936–) American physician and pharmacologist Murad was born in Whiting, Indiana, and graduated as an MD from the Western Reserve University School of Medicine, Cleveland, Ohio, in 1965. Three years later he gained his PhD from the department of… … Scientists
Murad, Ferid — (n. 14 sep. 1936, Whiting, Ind., EE.UU.). Farmacólogo estadounidense. Obtuvo su M.D. y Ph.D. en la Universidad Western Reserve (post., Case Western Reserve). Murad demostró que la nitroglicerina y los medicamentos cardiovasculares afines, inducen … Enciclopedia Universal
Murad — Ferid … Scientists
Ferid Murad — (* 14. September 1936 in Whiting, Indiana, USA) ist ein US amerikanischer Arzt und Pharmakologe, der 1998 den Nobelpreis für Medizin erhielt. Biografie Murad, Sohn eines … Deutsch Wikipedia
Ferid Murad — Saltar a navegación, búsqueda Ferid Murad Ferid Murad (14 de septiembre de 1936) es un médico y farmacólogo estadounidense. Hijo de un albanés John Murad (nacido como Xhabir Murat Ejupi) y de una estadounidense Henrietta Bowman nació en Whiting,… … Wikipedia Español
Ferid — ist ein Vor und Familienname. Vorname Ferid Alnar (1906–1978), türkischer Komponist Ferid Murad (* 1936), US amerikanischer Arzt und Pharmakologe Familienname Murad Ferid (1908–1998), deutscher Rechtswissenschaftler … Deutsch Wikipedia
Murad — I Murad, Ferid, amerikan. Mediziner, * Whiting (Ind.) 4. 9. 1936. M. erhielt mit L. J. Ignarro und R. F. Furchgott 1998 den Nobelpreis für Medizin oder Physiologie für die Entdeckung der Bedeutung des Stickoxids als Signalgeber im Herz… … Universal-Lexikon
Ferid Murad — Murad en 2008 Naissance 14 septembre 1936 Whiting (États Unis) Nationalité … Wikipédia en Français
Murad — (also spelled Mourad, Arabic: مراد) is a masculine Arabic given name, it may refer to: Contents 1 Given name 2 Surname 3 Other 4 See also … Wikipedia