Colebrook, Leonard

Colebrook, Leonard
born March 2, 1883, Guildford, Surrey, Eng.
died Sept. 29, 1967, Farnham Common, Buckinghamshire

English medical researcher.

He introduced (1935) the use of Prontosil, the first sulfonamide antibacterial drug, as a cure for puerperal fever. He also researched burn treatment, proving that sulfonamides and penicillin could control infection, urging wider use of skin grafting, and bringing the problem of tissue rejection to the attention of Peter Medawar.

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▪ British medical researcher
born March 2, 1883, Guildford, Surrey, Eng.
died Sept. 29, 1967, Farnham Common, Buckinghamshire

      English medical researcher who introduced the use of Prontosil, the first sulfonamide drug, as a cure for puerperal, or childbed, fever, a condition resulting from infection after childbirth or abortion.

      Colebrook joined researcher Almroth Wright in 1907 at St. Mary's Hospital. In 1926 Colebrook became interested in the incidence of puerperal fever in women who had just undergone childbirth. Nine years later, he obtained the newly discovered antibacterial drug Prontosil and used it to treat a woman who was dying of puerperal fever. The patient recovered, and the drug was next used successfully on a woman dying of septicemia (blood poisoning). By 1945, as a result of the widespread use of the drug, puerperal fever was no longer a common problem. Prontosil was also used to treat other diseases, including lobar pneumonia.

      At the outbreak of World War II, Colebrook went to France to investigate the treatment of burns. He established the efficacy of the sulfonamides and then of penicillin in controlling the infection of burns, urged the wider application of skin-grafting techniques to heal burns, and brought the problem of tissue rejection to the attention of Peter B. Medawar. Colebrook served as director of the Burns Investigation Unit of the Medical Research Council from 1942 to 1948.

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Universalium. 2010.

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  • Colebrook, Leonard — (2 mar. 1883, Guildford, Surrey, Inglaterra–29 sep. 1967, Farnham Common, Buckinghamshire). Investigador médico inglés. Introdujo (1935) el uso del Prontosil, la primera sulfonamida antibacteriana, como cura para la fiebre puerperal. También… …   Enciclopedia Universal

  • Leonard Colebrook — Naissance 2 mars 1883 Guildford, Surrey (Grande Bretagne) Décès 27 septembre 1967 (à 84 ans) Farnham Common, Buckinghamshire (Grande Bretagne) Nationalité …   Wikipédia en Français

  • Leonard Colebrook — Infobox Scientist name = PAGENAME box width = image size =150px caption = PAGENAME birth date = Birth date|1883|3|2 birth place = Guildford, Surrey death date = Death date and age|1967|9|27|1883|3|2 death place = Farnham Common, Buckinghamshire… …   Wikipedia

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