Bright disease


Bright disease
Type of nephritis without pus formation or edema.

It may or may not recur. The acute stage involves severe inflammation and back pain, deficient kidney function, swelling, and hypertension. In the subacute stage the kidney enlarges, blood does not reach its surface and red blood cells are damaged (leading to anemia), and its tissue breaks down, releasing excess blood protein into urine. In the chronic stage a small, shriveled, scarred kidney cannot filter nitrogen compounds from the blood, causing uremia. Treatment focuses on symptom relief.

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also called  glomerulonephritis or nephritis  
   inflammation of the structures in the kidney that produce urine: the glomeruli and the nephrons (nephron). The glomeruli are small round clusters of capillaries (capillary) (microscopic blood vessels (blood vessel)) that are surrounded by a double-walled capsule, called Bowman's capsule. Bowman's capsule in turn connects with a long tubule. The capsule and attached tubule are known as a nephron. In cases of glomerulonephritis, the glomeruli, the nephrons, and the tissues between nephrons are all afflicted. Glomerulonephritis may be caused by disease states that disrupt the normal function of the immune system (e.g., systemic lupus erythematosus), compromise the structure or function of the systemic vasculature (e.g., inflammation of the arteries (artery)), or damage the glomeruli (e.g., high blood pressure [ hypertension] or diabetic nephropathy). Glomerulonephritis can also arise from streptococcal infections such as strep throat. In some cases, however, a cause cannot be identified. Glomerulonephritis may occur only once or may recur. The successive stages of the disease are known as acute, subacute, and chronic.

      Acute glomerulonephritis is characterized by severe inflammation, renal (kidney) insufficiency, swelling, increased blood pressure, and severe back pain. Recovery is usually fairly complete after an episode of acute glomerulonephritis, but minor infections may do further damage to the kidneys and bring on the subacute and chronic stages. In the acute form of the disease, the kidneys are swollen, the capsule covering each kidney is taut and stretched, the surface is smooth and gray, and usually there are many small hemorrhages from the capillaries. The whole complex of glomeruli and nephrons swells.

      Subacute glomerulonephritis does not necessarily follow acute attacks; if it does develop, however, it has usually been preceded by an acute episode several months or years earlier. The kidney becomes considerably enlarged, the surface is smooth and pale, and the internal tissue is darker than normal. The paleness is due to the restriction of blood flow to the surface portion of the kidney and the high accumulation of fat ( lipid) droplets. Bowman's capsules become filled with excess surface (epithelial) cells (cell), red blood cells (erythrocyte), and mineral crystals. The nephron tubules begin to degenerate. Because of the breakdown of kidney tissue, a greater amount of blood protein is lost into urine than should normally be released. Red blood cells forced through the constricted glomeruli become crushed, distorted, and fragmented; their loss leads to anemia.

      Chronic glomerulonephritis usually follows the other two stages, if the affected person survives long enough, but it has been found in a few individuals who apparently have not had previous kidney disease. In this stage the kidney is reduced mostly to scar tissue. It is small and shrivelled, and the surface is granular. Because the blood cannot be filtered of waste products, abnormal quantities of nitrogenous substances in the blood cause the condition known as uremia. Treatment of all forms of glomerulonephritis is primarily directed toward controlling high blood pressure with antihypertensive agents and diuretics (diuretic) and through changes in diet, which include fluid restriction and decreased salt intake. Some patients respond to treatment with anti-inflammatory drugs. dialysis may be necessary to manage uremia.

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Universalium. 2010.

Look at other dictionaries:

  • Bright disease — (brīt) [Richard Bright, English physician, 1789–1858] see under disease …   Medical dictionary

  • Bright disease — term formerly often used for kidney disease with proteinuria, usually glomerulonephritis …   Medical dictionary

  • Bright, Richard — ▪ British physician born Sept. 28, 1789, Bristol, Gloucestershire, Eng. died Dec. 16, 1858, London  British physician who was the first to describe the clinical manifestations of the kidney disorder known as Bright s disease (Bright disease), or… …   Universalium

  • disease — diseasedly, adv. diseasedness, n. /di zeez /, n., v., diseased, diseasing. n. 1. a disordered or incorrectly functioning organ, part, structure, or system of the body resulting from the effect of genetic or developmental errors, infection,… …   Universalium

  • Bright's disease — is a historical classification of kidney diseases that would be described in modern medicine as acute or chronic nephritis. The term is no longer used, as diseases are now classified according to their more fully understood etiologies.It is… …   Wikipedia

  • Bright's disease — Bright s dis*ease [From Dr. Bright of London, who first described it.] (Med.) An affection of the kidneys, usually inflammatory in character, and distinguished by the occurrence of albumin and renal casts in the urine. Several varieties of Bright …   The Collaborative International Dictionary of English

  • Bright's disease — brīts n any of several kidney diseases marked esp. by albumin in the urine Bright Richard (1789 1858) British internist and pathologist. One of the foremost physicians of his day, Bright was particularly interested in diseases of the pancreas,… …   Medical dictionary

  • Bright — may refer to:*Brightness, the perception of how dark or light a source of luminance is *Being bright , describing colloquially, something with intelligence (trait) *The Brights movement, a social movement promoting the naturalistic… …   Wikipedia

  • Bright's disease — Bright s′ disease n. pat any kidney disease characterized by albuminuria and heightened blood pressure • Etymology: 1825–35; after R. Bright (1789–1858), English physician …   From formal English to slang

  • Bright's disease — chronic nephritis, 1831, so called for English physician Richard Bright (1789 1858), who in 1827 first described it …   Etymology dictionary


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