toxoid


toxoid
/tok"soyd/
n. a toxin rendered nontoxic by treatment with chemical agents or by physical means and used for administration into the body in order to produce specific immunity by stimulating the production of antibodies.
Also called anatoxin.
[1890-95; TOX(IN) + -OID]

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Bacterial toxin that has been made inactive but can still combine with or stimulate formation of antibodies.

In many bacterial diseases, the bacteria produce a toxin that causes the disease manifestations. Heating the toxin or treating it chemically converts it into a harmless toxoid that can be injected into a human or a nonhuman animal to confer immunity from subsequent infection. The vaccines for tetanus and diphtheria are toxoids.

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      bacterial (bacteria) poison (toxin) that is no longer active but retains the property of combining with or stimulating the formation of antibodies. In many bacterial diseases the bacteria itself remains sequestered in one part of the body but produces a poison (exotoxin) that causes the disease manifestations. Heating this poison or treating the poison with chemicals converts the exotoxin into a harmless toxoid; when the toxoid is injected into the body, it causes the formation of antibodies (antibody) that will also react with the active toxin and thus confer immunity from subsequent infection.

      Toxoids are used extensively in the production of vaccines (vaccine), the most prominent examples being the toxoids of diphtheria and tetanus, which are often given in a combined vaccine. Toxoids used in modern vaccines are commonly obtained by incubating toxins with formaldehyde at 37° C (98.6° F) for several weeks.

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Universalium. 2010.

Look at other dictionaries:

  • Toxoid — Tox oid, n. [Toxin + oid.] (Physiol. Chem.) An altered form of a toxin, possessing little or no toxic power. [Webster 1913 Suppl.] …   The Collaborative International Dictionary of English

  • toxoid — [täk′soid΄] n. [ TOX(IN) + OID] a toxin that has been treated, as with chemicals or heat, so as to eliminate the toxic qualities while retaining the antigenic properties …   English World dictionary

  • Toxoid — Toxoidimpfstoffe sind Impfstoffe, die Toxoide als wirksamen Bestandteil enthalten und bei aktiven Impfungen eingesetzt werden. Toxoide sind entgiftete Toxine, bei denen durch spezielle Verfahren die für die Giftigkeit verantwortlichen… …   Deutsch Wikipedia

  • Toxoid — A toxoid is a bacterial toxin (usually an exotoxin)whose toxicity has been weakened or suppressed either by chemical (formalin) or heat treatment, while other properties, typically immunogenicity, are maintained. Toxoids are used in vaccines as… …   Wikipedia

  • toxoid — A toxin that has been treated (commonly with formaldehyde) so as to destroy its toxic property but retain its antigenicity, i.e., its capability of stimulating the production of antitoxin antibodies and thus of producing an active immunity.For… …   Medical dictionary

  • Toxoid — To|xo|id 〈n. 11〉 entgiftetes Toxin, das im menschl. Körper keine Schäden, aber die Bildung von Antitoxinen bewirkt [→ Toxikum] * * * To|xo|id [↑ Toxin u. ↑ oid], das; s, e; veraltetes Syn.: Anatoxin: ein durch Zerstörung der toxophoren Gruppe… …   Universal-Lexikon

  • toxoid — noun a bacterial toxin that has been weakened until it is no longer toxic but is strong enough to induce the formation of antibodies and immunity to the specific disease caused by the toxin diphtheria toxoid • Syn: ↑anatoxin • Hypernyms:… …   Useful english dictionary

  • toxoid — noun Etymology: International Scientific Vocabulary Date: circa 1894 a toxin of a pathogenic organism treated so as to destroy its toxicity but leave it capable of inducing the formation of antibodies on injection …   New Collegiate Dictionary

  • toxoid — n. [Gr. toxikon, poison; eidos, form] A toxin released from its toxic properties, but not from its antigenic properties …   Dictionary of invertebrate zoology

  • toxoid — (tok soid) A bacterial exotoxin that has been modified so that it is no longer toxic but will still stimulate antitoxin formation when injected into a person or animal …   Dictionary of microbiology


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