renin

renin
/ree"nin/, n. Biochem.
a proteolytic enzyme secreted by the kidneys that is involved in the release of angiotensin.
[1890-95; REN(I)- + -IN2]

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▪ enzyme
      enzyme secreted by the kidney (and also, possibly, by the placenta) that breaks down protein and produces a rise in blood pressure. In the blood, renin acts on a fraction of the plasma proteins and releases angiotensin I. Angiotensin II is formed by the action of converting enzyme, which splits off two amino acids from the 10-amino-acid chain of angiotensin I. The resultant octapeptide (previously called hypertensin, or angiotonin) constricts arterioles, causing a rise in both systolic and diastolic blood pressure. It is one of the most active vasoconstrictors known; on a weight basis it is about six times as potent as norepinephrine. It also increases the secretion of cortisol and aldosterone by a direct action on the adrenal cortex.

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Universalium. 2010.

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  • renin — 1894, from L. renes “kidneys” + in …   Etymology dictionary

  • renin — [rē′nin] n. [< L renes, kidneys + IN1] a proteolytic enzyme, formed in the kidneys, that helps produce angiotensin, which is a powerful pressor responsible for hypertension …   English World dictionary

  • Renin — Protbox Name=Renin Photo=Renin.png Caption=Molecular structure of renin HGNCid = 9958 Symbol = REN AltSymbols = Names=Angiotensinogenase Chromosome = 1 Arm = q Band = 32 LocusSupplementaryData = Gene= Gene type= Protein length=406 Molecular… …   Wikipedia

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  • renin — A term originally used for a pressor substance obtained from rabbits kidneys, now an enzyme that converts angiotensinogen to angiotensin I. SYN: angiotensinogenase. * * * re·nin rē nənalso ren ən n a proteolytic enzyme of the blood that is… …   Medical dictionary

  • renin — noun ˈriːnɨn An circulating enzyme released by mammalian kidneys that converts angiotensinogen to angiotensin I. Because its activity ultimately leads to formation of angiotensin II and aldosterone, this hormone plays a role in maintaining blood… …   Wiktionary

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