morphine


morphine
morphinic /mawr fin"ik/, adj.
/mawr"feen/, n. Pharm.
a white, bitter, crystalline alkaloid, C17H19NO3·H2O, the most important narcotic and addictive principle of opium, obtained by extraction and crystallization and used chiefly in medicine as a pain reliever and sedative.
Also, morphia /mawr"fee euh/.
[1820-30; < G Morphin. See MORPHEUS, -INE2]

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It is among the most powerful naturally occurring compounds in its ability to reduce pain and distress; its calming effect protects the system against exhaustion in traumatic shock, internal hemorrhage, congestive heart failure, and other debilitating conditions. Morphine is usually given by injection but may be taken by mouth. Its most serious drawback is its addictiveness; many doctors are reluctant to use amounts adequate to relieve severe pain, even though short-term use in such cases rarely leads to drug addiction. This remains controversial even in terminal cases, when addiction is arguably irrelevant; another issue in such cases is that large doses depress respiration and may thus hasten death.

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drug
 narcotic analgesic drug used in medicine in the form of its hydrochloride, sulfate, acetate, and tartrate salts. Morphine was isolated from opium by the German chemist F.W.A. Sertürner in about 1804. In its power to reduce the level of physical distress, morphine is among the most important naturally occurring compounds, being of use in the treatment of pain caused by cancer and in cases where other analgesics have failed. It also has a calming effect that protects the system against exhaustion in traumatic shock, internal hemorrhage, congestive heart failure, and debilitated conditions (as certain forms of typhoid fever). It is most frequently administered by injection to ensure rapid action, but it is also effective when given orally.

      Morphine produces a relaxed, drowsy state and many side effects that result from the depression of the respiratory, circulatory, and gastrointestinal systems. It also is an emetic and a general depressant. The most serious drawback to the drug is its addictiveness.

      Morphine, an opium alkaloid, can be converted into heroin, which shows a considerably stronger euphoric effect and is so powerfully addictive that its manufacture is legally prohibited in many countries. Other derivatives of morphine include the analgesics methylmorphine ( codeine), ethylmorphine, dihydrocodeinone, and dihydromorphinone and the emetic apomorphine.

      The structure of morphine proposed in the 1920s by J.M. Gulland and R. Robinson was confirmed in 1952 by its total synthesis, accomplished by M. Gates and G. Tschudi. Synthetic organic chemistry also has provided a number of compounds (as meperidine, methadone, and pentazocine) that have in part supplanted morphine in medical use.

      Morphine is extracted from the dried milky exudate of the unripe seed capsule of the opium poppy (Papaver somniferum). It occurs as colourless crystals or a white crystalline powder.

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Universalium. 2010.

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  • Morphine — Datos generales Origen Cambridge, Massachusetts, Estados Unidos Información artística …   Wikipedia Español

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  • Morphine — Mor phine, n. [From Morpheus: cf. F. morphine.] (Chem.) A bitter white crystalline alkaloid found in opium, possessing strong narcotic properties, and much used as an anodyne; called also {morphia}, and {morphina}. [1913 Webster] …   The Collaborative International Dictionary of English

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  • morphiné — morphiné, ée (entrée créée par le supplément) (mor fi né, née) adj. Terme de physiologie expérimentale. Qui a reçu dans ses tissus de la morphine. •   On prend une grenouille morphinée, HENNEGUY Etude sur l action des poisons, p. 23, Montpellier …   Dictionnaire de la Langue Française d'Émile Littré

  • morphine — (n.) chief alkaloid of opium, 1828, from Fr. morphine or Ger. Morphin (1816), name coined by German apothecary Friedrich Sertürner (1783 1840) in reference to L. MORPHEUS (Cf. Morpheus), Ovid s name for the god of dreams, from Gk. morphe form,… …   Etymology dictionary

  • morphine — [môr′fē əmôr′fēn΄] n. [Ger morphin or Fr morphine < ModL morphium, so named (1811) by F. W. A. Sertürner (1783 1841), Ger pharmacist < L Morpheus: see MORPHEUS] a bitter, white or colorless, crystalline narcotic alkaloid, C17H19NO3·H2O,… …   English World dictionary

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  • morphine — ► NOUN ▪ a narcotic drug obtained from opium and used medicinally to relieve pain. ORIGIN named after the Roman god of sleep, Morpheus …   English terms dictionary

  • Morphine — This article is about the drug. For other meanings, see Morphine (disambiguation). Morphia redirects here. For other uses, see Morphia (disambiguation). Not to be confused with Morphinae, Morphea, or Morpholine. Morphine …   Wikipedia


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