gout


gout
/gowt/, n.
1. an acute, recurrent disease characterized by painful inflammation of the joints, chiefly those in the feet and hands, and esp. in the great toe, and by an excess of uric acid in the blood.
2. a mass or splash, as of blood; spurt.
[1250-1300; ME goute < OF < L gutta a drop (of fluid); gout in the feet formerly was attributed to drops of a corrupted humor]

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Hereditary metabolic disorder in which excess uric-acid salts, normally excreted in urine, are deposited as needle-sharp crystals in joints, causing attacks of severe inflammation.

The most common site is the base of the big toe. One of the oldest diseases in medical literature, gout is far more common in men. Attacks usually do not begin until middle age. They cause heat, redness, and extreme tenderness and pain and often subside in a week or two. Colchicine is used to treat acute attacks. Drugs such as allopurinol inhibit uric-acid synthesis.

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      hereditary metabolic disorder characterized by recurrent acute attacks of severe inflammation in one or more of the joints (joint) of the extremities. Gout results from the deposition, in and around the joints, of uric acid salts, which are excessive throughout the body in persons with the disorder. Uric acid is the metabolic end product of purines (purine) and normally is steadily excreted into the urine. The enzyme defect that leads to abnormal concentration of the substance in the body is unknown. Gout accounts for at least 5 percent of all cases of arthritis. It is uncommon, however, in women; the male-female ratio is 20:1. Pseudogout (chondrocalcinosis) is a similar condition caused by deposits of calcium pyrophospate crystals in the joints.

      Although gout is probably inborn, the initial attack of acute joint inflammation, or gouty arthritis, usually does not appear until middle age. Any peripheral joint may be affected, but for some reason the joint at the base of the big toe is especially susceptible. Symptoms include redness of the skin and extreme tenderness, warmth, and pain of the affected joints. An attack, even when untreated, may subside in a week or two. Attacks may come and go without apparent reason, but there are a number of precipitating factors, including acute infection, emotional upset, diuresis, surgery, trauma, and the administration of certain medications. Precipitation of uric acid in the joint cartilage precedes the first attack. In some cases, continued deposition of uric acid salts may cause knobby deformities (tophi) and may also occur in cartilage that is not associated with the joints, such as the rim of the ear.

      Treatment for an acute attack of gout includes the administration of nonsteroidal anti-inflammatory drugs (NSAIDs) such as indomethacin and naproxen. Corticosteroids may also be injected into the affected joint to reduce inflammation. A medication called colchicine may be administered if NSAIDs and corticosteroids are not effective. Medications such as allopurinol and probenecid, which inhibit the synthesis of uric acid in the body, are used to treat recurrent acute attacks.

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Universalium. 2010.

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Look at other dictionaries:

  • goût — goût …   Dictionnaire des rimes

  • goût — [ gu ] n. m. • goust XIIIe; lat. gustus I ♦ 1 ♦ Sens grâce auquel l homme et les animaux perçoivent les saveurs propres aux aliments. ⇒ 1. goûter; déguster, gustatif. La langue et le palais, organes du goût chez l homme. Aliment agréable au goût …   Encyclopédie Universelle

  • gout´i|ly — gout|y1 «GOW tee», adjective, gout|i|er, gout|i|est. 1. diseased or swollen with gout. 2. of gout; caused by gout: »gouty arthritis …   Useful english dictionary

  • gout|y — gout|y1 «GOW tee», adjective, gout|i|er, gout|i|est. 1. diseased or swollen with gout. 2. of gout; caused by gout: »gouty arthritis …   Useful english dictionary

  • Gout — (gout), n. [F. goutte a drop, the gout, the disease being considered as a defluxion, fr. L. gutta drop.] [1913 Webster] 1. A drop; a clot or coagulation. [1913 Webster] On thy blade and dudgeon gouts of blood. Shak. [1913 Webster] 2. (Med.) A… …   The Collaborative International Dictionary of English

  • gout — gout; gout·i·ly; gout·i·ness; gout·ish; ra·gout; …   English syllables

  • Gout — 〈 [gu:] m.; Gen.: s; Pl.: unz.; geh.〉 Geschmack, Neigung, Wohlgefallen; »bon Gout« haben, verraten guten Geschmack; diese Arbeit ist überhaupt nicht nach seinem Gout [Etym.: <frz. goût »Geschmack«] …   Lexikalische Deutsches Wörterbuch

  • gout — c.1200, from O.Fr. gote (10c., Mod.Fr. goutte) gout; drop, from L. gutta a drop, in M.L. gout, of unknown origin. The disease was thought to be caused by drops of viscous humors seeping from the blood into the joints, which turned out to be close …   Etymology dictionary

  • gout — [gout] n. [ME goute < OFr, gout, lit., a drop < L gutta, a drop: orig. attributed to a discharge of drops of humors] 1. a hereditary form of recurrent, acute arthritis with swelling and severe pain, resulting from a disturbance of uric acid …   English World dictionary

  • goût — GOÛT: Ce qui est simple est toujours de bon goût. Doit toujours se dire à une femme qui s excuse de la modestie de sa toilette …   Dictionnaire des idées reçues

  • Gout — [gu:] der; s, s <aus gleichbed. fr. goût, dies aus lat. gustus »das Kosten«> Geschmack, Wohlgefallen; vgl. ↑Hautgout …   Das große Fremdwörterbuch


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