marble bone disease

marble bone disease

also called  osteopetrosis  or  Albers-Schönberg disease 

      rare hereditary congenital disorder in which the bones (bone) become extremely dense, hard, and brittle. The disease progresses as long as bone growth continues; the marrow (bone marrow) cavities become filled with compact bone, and severe anemia results. In marble bone disease, bone-resorbing cells called osteoclasts (osteoclast) are either reduced in number or are ineffective. Fractures (fracture) are frequent; deafness and loss of vision may occur because cranial nerves (cranial nerve) become compressed by the narrowing of their passageways as bone is deposited in the skull. Severe cases may be fatal; individuals with mild cases of the disorder may have a normal life expectancy. Treatment may include gamma interferon, a protein that delays progression of the disease; bone marrow transplantation; or calcitriol, a vitamin D compound that stimulates osteoclasts to dissolve and absorb bone.

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Universalium. 2010.

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Look at other dictionaries:

  • marble bone disease — n OSTEOPETROSIS (a){{}}(b) * * * osteopetrosis …   Medical dictionary

  • marble bone disease — noun see marble bone …   Useful english dictionary

  • marble-bone disease — see osteopetrosis …   Medical dictionary

  • marble-bone disease — see osteopetrosis …   The new mediacal dictionary

  • bone disease — Introduction  any of the diseases or injuries that affect human bones (bone). Diseases and injuries of bones are major causes of abnormalities of the human skeletal system (skeletal system, human). Although physical injury, causing fracture,… …   Universalium

  • marble bone — noun or marble bone disease : osteopetrosis …   Useful english dictionary

  • marble bones disease — noun an inherited disorder characterized by an increase in bone density; in severe forms the bone marrow cavity may be obliterated • Syn: ↑osteopetrosis, ↑Albers Schonberg disease • Hypernyms: ↑genetic disease, ↑genetic disorder, ↑genetic… …   Useful english dictionary

  • Остеопетроз (Osteopetrosis), Болезнь Альберс-Шенберга (Albers-Schonberg Disease), Болезнь Мраморная (Marble-Bone Disease) — врожденное заболевание, характеризующееся злокачественным остеосклерозом с ломкостью костей и анемией. Пораженные кости на рентгенограмме выглядят необычно темными. См. также Остеосклероз. Источник: Медицинский словарь …   Медицинские термины

  • Болезнь Мраморная (Marble-Bone Disease) — см. Остеопетроз. Источник: Медицинский словарь …   Медицинские термины

  • Disease — Illness or sickness often characterized by typical patient problems (symptoms) and physical findings (signs). Disruption sequence: The events that occur when a fetus that is developing normally is subjected to a destructive agent such as the… …   Medical dictionary

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