ligase

ligase
/luy"gays, -gayz/, n. Biochem.
any of a class of enzymes that catalyze the joining of two molecules by formation of a covalent bond accompanied by the hydrolysis of ATP.
[1961; < L lig(are) to tie, bind + -ASE]

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also called  Synthetase 

      any one of a class of about 50 enzymes that catalyze reactions involving the conservation of chemical energy and provide a couple between energy-demanding synthetic processes and energy-yielding breakdown reactions. They catalyze the joining of two molecules, deriving the needed energy from the cleavage of an energy-rich phosphate bond (in many cases, by the simultaneous conversion of adenosine triphosphate [ATP] to adenosine diphosphate [ADP]). A ligase catalyzing the formation of a carbon-oxygen bond between an amino acid and transfer RNA is called amino acid–RNA ligase. Carbon–nitrogen (C−N) bonds are formed by the action of such enzymes as amide synthetases and peptide synthetases.

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Universalium. 2010.

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  • ligase — n. (Biochem.) An enzyme which catalyzes creation of a covalent bond between two substrates, resulting in a larger product which is a combination of the two starting materials; especially, {DNA ligase}, an enzyme which creates a phosphate bond… …   The Collaborative International Dictionary of English

  • ligase — [lī′gās΄, lī′gāz΄] n. any of a class of enzymes that act as catalysts in chemical reactions in which molecules are linked together, as in the synthesis and repair of DNA or in the formation of recombinant DNA …   English World dictionary

  • Ligase — In biochemistry, a ligase (from the Latin verb ligāre mdash; to bind or to glue together ) is an enzyme that can catalyse the joining of the sugar phosphate backbones of Okazaki fragments of DNA. Generally ligase catalyses the following reaction …   Wikipedia

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